![]() ![]() Surprising to the congregation, Ron Kenoly lead series of praise songs like “eeh eeh my God is good oh”, “When Jesus say yes”, “Wami le le Wami le le”, “Alpha, Omega, you are worthy of my praises”and “Today oh, I will lift up my voice in praise”. Panam Percy Paul a very close friend to Pasto Sam Oye of The Transforming Church who admonished the choir for Excellent, Creativity, Productivity and Humility to attain a greater height. Ron stated, that they don’t want to go through what all he went through like Accident, Sickness, Plane Crash, Divorce and so many others too. He called on the music ministers (Choir) in the Church for impartation. ![]() Hunter, Ron’s producer who taught the congregation his song and ministered along side with Ron Kenoly – “Blessed Elohim”. The heart to bring up more worshippers like himself and Panam Percy was more of his talks during his ministration, which lead to the invitation of David F. The popular gospel minister, Ron Kenoly who has been with Intergrity music started his ministration with bringing to memory his songs like “Sing out the Lord is here”, “God is able”, “Lift him up”, “Who am I (Ka bi o Osi o)”, Yahuwah (You are)”, “You are the pillar that holds my life”, “Anointing fall on me”, “Be glorified”, “Use me”, “Hallowed be your name”, Righteous Peace Joy in Holy Ghost” and “Ancient of days”. Ron started with a tribute for Andre Cruch who passed away last week by singing some of his songs along side with Panam Percy Paul like “Soon and very soon, we are going to see the Lord…”, “To God be the glory,…” and “Hallelujah”. Ron Kenoly when invited to the stage came up with his beautiful wife Diana Kenoly who sang along with him through out the ministration. The visit of Ron & Diana Kenoly along with his crew to The Transforming Church, Gwarimpa headed by Pastor Sam Oye in the city of Abuja was an awesome one if you were present during the inspiring service on Sunday the 11th of January with “Naija Gospel” present in for the event.īringing Ron to the stage was a surprise as Dr. ![]()
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![]() ![]() VectorWorks Architect has some of the most advanced 3D solids and surface modeling capabilities available among architectural products. I think we can find a way to communicate this to the customer in a positive fashion and focus our competitive efforts outside the company.Įxcluding the price factor, why should an architect select VectorWorks over one of the many competitors?įree-form modeling is becoming increasingly important to architectsįree-form modeling is becoming increasingly important to architects as construction techniques advance and architects shift to conceptualization in 3D. Where our products overlap in architectural design, our products take very different approaches to fulfilling customer requirements and solving customer challenges. Longer-term, we're talking with the marketing team at Graphisoft US to see how we might position our products together in the US. Nemetschek has a history of acquiring companies and allowing them to compete freely in the marketplace, much as they did when they acquired us (formerly Diehl Graphsoft) in 2000. In the near-term, you can expect very few changes. What changes can Americans expect from Nemetschek after the recent acquisition of Graphisoft? Since then, I've worked in variety of development and product management roles until taking over as CEO in 2005 when our founder, Richard Diehl, retired. ![]() I joined the company in 1985 as employee #2 to expand our development team. But we have a large contingent of customers in a few big sub-markets, such as exhibit design, interior design and mechanical drafting. #Allplan engineering price movie#Our top customer markets are architecture, landscape design and TV, movie and theater lighting design, as well as scene and set design. Our biggest markets are Japan, the US, the UK and Germany. The VectorWorks product line is sold broadly around the world. We were founded as Diehl Graphsoft in 1985, so we have a long history of CAD development, and it has always been our primary mission. ![]() Our division is in charge of the development and sales of the VectorWorks family of products worldwide. Nemetschek North America (based in Maryland) is a wholly-owned subsidiary of Nemetschek AG, a German technology company. I invited Sean to participate in the following interview:Ĭan you tell us a bit about yourself and your company? The recent acquisition of Graphisoft by Nemetschek was a great opportunity to contact Sean. Novedge has been a VectorWorks' reseller in the United States for a few years. Sean Flaherty is the CEO of Nemetschek North America, the American branch of Nemetschek AG, the German company that is well known worldwide for products like VectorWorks and Allplan. ![]() ![]() ![]() Incidence and severity of Adverse Events were coded according to NCI Common Terminology Criteria (NCI CTCAE, Version 3.0). Routine anti-emetic prophylaxis was not given. The starting dose was 45 mg/m 2, targeted to administer 1/10 th of the exposure at MTD in the dog, the most sensitive species in toxicology studies. Danusertib was administered via central line as a 24-h IV infusion on Day 1 of a 14-day treatment cycle. The drug product was stored at 2–8☌, protected from light and brought to room temperature shortly before use. Each vial contained 15 mL of solution (10 mg/mL) corresponding to 150 mg of danusertib. (Nerviano, Italy) and supplied as 1% (w/v) sterile solution in 20/26 mL type I glass vials. ![]() Danusertib was manufactured by Nerviano Medical Sciences S.r.l. I DOSER DOSES FOR FREE TRIALThis was a Phase I, open-label, non-randomized, dose-escalation trial conducted at 2 USA sites. All patients were adults (age >18 yrs) and gave written informed consent according to local IRB and Federal guidelines. Patients with previous high-dose chemotherapy requiring hematopoietic stem cell rescue, known brain or leptomeningeal metastasis, active inflammatory bowel disease, partial or complete bowel obstruction or chronic diarrhea, abnormal left ventricular function, severe cardiovascular disease, cardiac dysrhythmias ≥Grade 2, and active infections were excluded. Eligibility criteria also included Eastern Cooperative Oncology Group performance status ≤ 1 prior radiation completed ≥2 weeks prior to enrollment and no more than 25% of bone marrow irradiated life expectancy ≥12 weeks normal blood pressure (≤140/90 mmHg) with or without treatment and baseline laboratory data indicating acceptable bone marrow, liver and kidney function. Patients with histological or cytological evidence of advanced refractory cancer lacking options for established curative or life-prolonging therapy were eligible. To the best of our knowledge danusertib was the first Aurora kinase inhibitor in the clinic. In addition an increase in peripheral blood pressure was observed after IV bolus and 6-h infusion in rats, but not in dogs.īased on this broad spectrum of preclinical activity and favorable toxicology profile, we performed a phase I study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of danusertib in patients with refractory solid tumors. ![]() Renal effects, however, are only seen at high drug exposure. Danusertib also has significant antitumor activity in transgenic tumor models with a favorable preclinical safety profile( 16) principal target organs of danusertib are the hemolymphopoietic system, GI tract, male reproductive organs and kidneys. Thus, inhibition of histone H3 phosphorylation may be a potential biomarker of danusertib biological activity. Danusertib inhibits Aurora-B phosphorylation at serine 10 of histone H-3, a protein implicated in chromosome condensation. In vitro studies have shown that danusertib causes a failure of cell division, resulting in polyploidy and reduction in viability. Danusertib shows dominant Aurora B Kinase inhibition( 16) with additional activity against bcr-abl, including the T315I mutation. Several AK inhibitors with diverse pharmacological properties are in clinical trials( 8– 15).ĭanusertib is active in vitro against a wide range of cancer cell lines with sub-micromolar IC 50 values for inhibition of proliferation. Aurora B is a chromosome passenger protein required for histone H3 phosphorylation, chromosome segregation and cytokinesis( 5– 7). Aurora A, required for spindle assembly, localizes to centrosomes. AKs are essential for mitosis( 1) and cytokinesis with upregulation in many malignancies, including pancreatic( 2), colorectal( 3), ovarian( 3) and esophageal cancer( 4). Danusertib is a small molecule 3-aminopyrazole derivative that potently inhibits all Aurora Kinase (AK) family members (A, -B & -C). ![]() |
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